Assessment of effectiveness of complex treatment of apical and marginal periodontitis with thiotriazoline and chloramphenicol ointment

Marta Holeyko, Volodymyr Zubachyk


Introduction. Chronic combined periodontal and periapical lesions have a negative impact on the human organism, since they are a source of intoxication and sensitization causing progression of infection, development of focal sequelae and secondary immunodeficiency. Problem of successful treatment of apical and marginal periodontitis is associated with a significant prevalence of these diseases, a complexity of medical procedures, a substantial proportion of failures and complications, and with a lack of long‑term stability of gained results.
Aim. The aim of this work was to investigate clinical effectiveness of drug formulation with thiotriazoline and chloramphenicol in the integrated treatment of combined apical and marginal periodontitis.
Meterial and methods. The condition of oral cavity of the 65 patients with combined lesions of periodontal and endodontic tissues before and after treatment was studied. Outcomes measured were X‑ray examination, probing depth, OHI‑S, PMA, PI, SBI indices. The complex treatment has been worked out in the patients of main group and the ointment with thiotriazoline and chloramphenicol was introduced in the scheme of periodontal treatment
Results and conclusions. Results of applied treatment indicated to the acceleration of healing process, reduction of exudation period and decrease of exacerbations frequency in the patients of main group. Clinical experience also demonstrated positive dynamic in changes of periodontal indices after the conducted treatment.


chronic generalized periodontitis; apical periodontitis; treatment; ointment with thiotriazoline and chloramphenicol

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