Clinical outcomes of conjugated linoleic acid supplementation in the overweight and the obese: a study protocol

Klaudia Łochocka, Aleksandra Glapa, Jan Krzysztof Nowak, Monika Duś-Żuchowska, Katarzyna Grabańska, Paweł Bogdański, Ewa Fidler, Edyta Mądry, Jarosław Walkowiak

Abstract


This is the protocol of a study aiming to assess the impact of conjugated linoleic acid (CLA) on body mass and composition, carbohydrate and fat digestion and absorption, total energy expenditure, lipid profile, polyunsaturated fatty acids levels, markers of endothelial dysfunction and mineral status in humans. Seventy-four adult volunteers (BMI ≥ 25 kg/m2) will be randomized to receive 3.0 g of 80% CLA (50:50 cis-9, trans-11 and trans-10, cis-12 isomers) or 3.0 g of linoleic acid daily for 3 months. A range of parameters will be measured at baseline and after the intervention.

Keywords


obesity; randomized; digestion; absorption; body composition; lipid profile; endothelial dysfunction; mineral status; breath test; 13C

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References


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